Dosing

ZENPEP offers MORE dosing flexibility

Looking for dosing in EPI patients with CF?

Calculate the starting and maximum lipase per day for your patient

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Lipase calculation
Lipase calculation

Power up your patients'
PERT experience with the
high-strength ZENPEP capsules

Capsules not actual size.

Only ZENPEP meets the ACG-recommended dose
in a single capsule per meal.1-3*

Rule Rule
  • This illustration is intended to be an example. ZENPEP capsules represent nearest capsule count within recommended dosing range.
  • For patients on the lower end of the weight range, a lower dose may be appropriate.
  • Do not exceed 2,500 lipase units/kg/meal, 10,000 lipase units/kg/day, or 4,000 lipase units/g fat ingested/day in adult and pediatric patients greater than 12 months of age without further investigation.
  • ZENPEP 40K and/or 60K may not be appropriate for all patients. ZENPEP is available in 3K, 5K, 10K, 15K, 20K, 25K, 40K, and 60K USP units of lipase.
  • Therapy should be initiated at the lowest recommended dose and gradually increased.
  • ZENPEP capsules and capsule contents should not be crushed or chewed. ZENPEP should be taken with every meal and snack. Usually half the prescribed dose for an individualized full meal should be given with each snack.
Table Table

References: 1. ZENPEP. Package insert. Aimmune Therapeutics, Inc. Bridgewater, NJ; July 2025. 2. Fryar CD, Carroll MD, Gu Q, Afful J, Ogden CL. Anthropometric reference data for children and adults: United States, 2015–2018. Vital Health Stat. 2021;3(46):1-44. 3. Gardner TB, Adler DG, Forsmark CE, Sauer BG, Taylor JR, Whitcomb DC. ACG Clinical Guideline: chronic pancreatitis. Am J Gastroenterol. 2020;115(3):322-339. doi:10.14309/ajg.0000000000000535