Dosing

ZENPEP offers MORE dosing flexibility

Looking for dosing in EPI patients with CF?

Only ZENPEP offers 8
different strengths,

which allows you to customize
treatment as needed and minimize
pill burden

Calculate the starting
and maximum
lipase per day for
your patient

Calculate the starting
and maximum lipase per
day for your patient

Use the calculator
Lipase calculation

This dosing calculator is for informational purposes only and does not replace clinical judgment. Refer to the full Prescribing Information for complete dosing instructions.

Lipase calculation
Lipase calculation

Power up your patients'
PERT experience with
the high-strength
ZENPEP capsules

Only high-strength ZENPEP offers your adult patients MORE lipase per capsule for a powerful starting dose in a single capsule.

Capsules not actual size.

Only ZENPEP meets the
ACG-recommended
dose in a single
capsule per meal1,2*

Only ZENPEP meets the ACG-recommended dose
in a single capsule per meal1,2*

Rule Rule
  • This illustration is intended to be an example; ZENPEP capsules represent nearest capsule count within recommended dosing range
  • For patients on the lower end of the weight range, a lower dose may be appropriate
  • For patients on the lower end of the weight range, a lower dose may be appropriate
  • Do not exceed 2,500 lipase units/kg/meal, 10,000 lipase units/kg/day, or 4,000 lipase units/g fat ingested/day in adult and pediatric patients greater than 12 months of age without further investigation
  • ZENPEP 40K and/or 60K may not be appropriate for all patients. ZENPEP is available in 3K, 5K, 10K, 15K, 20K, 25K, 40K, and 60K USP units of lipase
  • Therapy should be initiated at the lowest recommended dosage and individualize the dosage based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet 
  • ZENPEP capsules and capsule contents should not be crushed or chewed. ZENPEP should be taken with every meal and snack. Usually, half the prescribed dose for an individualized full meal should be given with each snack
Table Table

References: 1. ZENPEP. Package insert. Aimmune Therapeutics, Inc. Bridgewater, NJ; July 2025. 2. Fryar CD, Carroll MD, Gu Q, Afful J, Ogden CL. Anthropometric reference data for children and adults: United States, 2015–2018. Vital Health Stat. 2021;3(46):1-44. 3. Gardner TB, Adler DG, Forsmark CE, Sauer BG, Taylor JR, Whitcomb DC. ACG Clinical Guideline: chronic pancreatitis. Am J Gastroenterol. 2020;115(3):322-339. doi:10.14309/ajg.0000000000000535