About EPI
Insufficient PERT dosing can cause some patients with EPI to fall through the cracks
Looking for information about EPI in patients with CF?CF=cystic fibrosis; EPI=exocrine pancreatic insufficiency; PERT=pancreatic enzyme replacement therapy.
Limitations of PERT can cause patients like
Grace to fall through the
cracks
Meet Grace, 42
- Started experiencing gastrointestinal symptoms 3 years ago
- Made changes to her diet but symptoms persisted
- Diagnosed by her primary care physician with irritable bowel syndrome with diarrhea (IBS-D) and prescribed an anti-diarrheal
Not an actual patient.
480,000 to 960,000 lipase units may seem high, but that's what a healthy pancreas produces each meal1*
*The estimated "normal" amount of pancreatic enzyme secretion 4 hours after a meal varies with content and volume of meal ingested. Data estimated from a study using test meals of 300 to 600 kcal.
See what it looks like when a pancreas is functioning properly, and when it's not, for patients with EPI who need ZENPEP.
Watch the video
1 in 4 patients with EPI was originally diagnosed with another GI condition2†
†In a survey of 500 clinicians and 1,001 adult patients with chronic GI issues.
GI symptoms could indicate EPI,
another disorder, or both3-13
If a patient presents with any of these
symptoms, especially if they get worse after a
fatty meal, it could
be EPI14
This chart is for informational purposes only. It is not a complete list of symptoms for each disorder and
is not intended to be used to diagnose, treat, or care for any particular patient.
GI=gastrointestinal.
6 months later:
- Grace’s symptoms remained, and she was referred to a gastroenterologist
- She was diagnosed with EPI and chronic pancreatitis
Not an actual patient.
Patients with the following underlying conditions
may also have
EPI15,16
- IBS-D17
- Crohn's disease18
- Ulcerative colitis18
- Celiac disease (with current or persistent diarrhea)19,20
‡Surgery for pancreatic neoplasms. The Whipple procedure is associated with the highest rate of EPI (up to 98%), while pylorus-preserving intervention has a slightly lower rate (80%-90%).
Grace’s doctor advised her to change her diet and stop smoking
Not an actual patient.
