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For US Healthcare Professionals Only

Important Safety Information
Prescribing Information
Patient site
Request Samples
Request a Rep
  • About EPI
  • About ZENPEP
  • Dosing Flexibility
  • Copay Support
Efficacy
Efficacy & Safety
dosing
Dosing
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MOA
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Coverage
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Resources
EPI Due
to CF
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to CF

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IMPORTANT SAFETY INFORMATION

Warnings and Precautions

Fibrosing Colonopathy

  • Fibrosing colonopathy is a rare serious adverse reaction initially described in association with use of high-dose pancreatic enzyme products, usually with use over a prolonged period of time and most commonly reported in pediatric patients with cystic fibrosis. Exercise caution when doses of ZENPEP exceed 2,500 lipase units/kg of body weight per meal (or greater than 10,000 lipase units/kg of body weight per day or 4,000 lipase units/g fat ingested/day).

Irritation of the Oral Mucosa

  • Crushing or chewing ZENPEP capsules or mixing the capsule contents in foods having a pH greater than 4.5 can cause irritation of the oral mucosa. Do not crush or chew capsules or capsule contents.

Hyperuricemia

  • Pancreatic enzyme products contain purines that may increase blood uric acid levels. High dosages have been associated with hyperuricosuria and hyperuricemia.

Risk of Viral Transmission

  • There is theoretical risk for transmission of viral disease. However, no cases of transmission of an infectious illness associated with the use of porcine pancreatic extracts have been reported.

Hypersensitivity Reactions

  • Severe hypersensitivity reactions including anaphylaxis, asthma, hives, and pruritus have been reported with pancreatic enzyme products.
  • Monitor patients with a known hypersensitivity reaction to proteins of porcine origin for hypersensitivity reactions during treatment with ZENPEP.

Adverse Reactions

  • The most common adverse reactions (≥6% of patients treated with ZENPEP) were headache, contusion, cough, and early satiety.

Additional Important Safety Information

  • Do not substitute other pancreatic enzyme products for ZENPEP.
Please see the full Prescribing Information for ZENPEP.

INDICATIONS AND USAGE

ZENPEP® is indicated for the treatment of exocrine pancreatic insufficiency in adults and pediatric patients.

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Calculator Try the dosing calculator >
ZENPEP Tool Logo

This calculator is intended for adults
weighing 115 lb to 265 lb

How much does your EPI
patient weigh?

lb
This calculator is
intended for adults
weighing ≥115 lb
Measurement Bar
Light Weight
Heavy Weight
Scale Base
ZENPEP Tool Logo

This calculator is for use with adult patients with EPI weighing 115 lb to 265 lb

Estimate the range of lipase for your patients with EPI

Input your patient’s weight (lb)
lb
This dosing calculator is for informational purposes only and does not replace clinical judgment. Refer to the full Prescribing Information for complete dosing instructions and safety information.

LIPASE

Maximum
dose per day
775,644 Max dose
per day
Maximum dose
per meal
193,910 Max dose
per meal
4x - 40K
Minimum starting
dose per meal
38,782Min starting
dose per meal
1x - 40K
Pill strength
40K 60K
See all ZENPEP pill
strength options
Rx icon Sample Rx for
starting dose

 

pill icon

In addition to weight, individualize the dosage based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet.1

*Based on 2 snacks/3 meals per day.
EPI=exocrine pancreatic insufficiency.
ZENPEP capsules and capsule contents should not be crushed or chewed.
ZENPEP should be taken with every meal and snack. Usually, half of the prescribed dose for an individualized full meal should be given with each snack.1
Therapy should be initiated at the lowest recommended dosage and individualized to the dosage based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet.1

Input your patient’s weight (lb)
lb
This dosing calculator is for informational purposes only and does not replace clinical judgment. Refer to the full Prescribing Information for complete dosing instructions and safety information.

This calculator is intended for adults weighing 115 lb to 265 lb.

ZENPEP® (pancrelipase) offers flexible
dosing options for your patients


Pills left Pills right

Capsules not to scale.

  • Do not substitute other pancreatic enzyme products for ZENPEP
  • ZENPEP capsules and capsule contents should not be crushed or chewed
  • ZENPEP should be taken with every meal and snack. Usually, half of the prescribed dose for an individualized full meal should be given with each snack1
  • Therapy should be initiated at the lowest recommended dosage and individualize the dosage based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet1

This calculator is intended for adults
weighing ≥115 lb

Please see other available ZENPEP® (pancrelipase) dosing strengths below.


Pills left Pills right

Capsules not to scale.

  • Do not substitute other pancreatic enzyme products for ZENPEP
  • ZENPEP capsules and capsule contents should not be crushed or chewed
  • ZENPEP should be taken with every meal and snack. Usually, half of the prescribed dose for an individualized full meal should be given with each snack1
  • Therapy should be initiated at the lowest recommended dosage and individualize the dosage based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet1

Determine lipase dosage for pediatric patients with this calculator.


Example starting dose

ZENPEP® (pancrelipase)
40K lipase units

Pill(s) per meal: [1]

Pill(s) per day: [4]

30-day total: [120 pills]

Note: Take with every meal and snack.1


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